Won-Ki Kim Selected Research

Dextromethorphan (Racemethorphan)

12/2006	3-Hydroxymorphinan, a metabolite of dextromethorphan, protects nigrostriatal pathway against MPTP-elicited damage both in vivo and in vitro.
4/2005	The dextromethorphan analog dimemorfan attenuates kainate-induced seizures via sigma1 receptor activation: comparison with the effects of dextromethorphan.
5/2004	Dimemorfan prevents seizures induced by the L-type calcium channel activator BAY k-8644 in mice.
1/2003	Metabolism to dextrorphan is not essential for dextromethorphan's anticonvulsant activity against kainate in mice.

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Won-Ki Kim Research Topics

Disease

11	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 01/2022 - 09/2004
11	Ischemia 01/2022 - 09/2003
10	Seizures (Absence Seizure) 08/2011 - 12/2002
9	Stroke (Strokes) 01/2022 - 04/2006
8	Infarction (Infarctions) 06/2016 - 09/2004
7	Inflammation (Inflammations) 01/2022 - 04/2005
6	Ischemic Stroke 01/2022 - 05/2011
5	Brain Ischemia (Cerebral Ischemia) 01/2022 - 09/2004
5	Cerebral Infarction 01/2022 - 05/2011
5	Mitochondrial Diseases (Mitochondrial Disease) 12/2017 - 02/2009
5	Parkinson Disease (Parkinson's Disease) 12/2013 - 12/2006
5	Neurodegenerative Diseases (Neurodegenerative Disease) 12/2013 - 08/2004
4	Neoplasms (Cancer) 05/2021 - 01/2006
4	Atherosclerosis 12/2019 - 08/2012
3	Edema (Dropsy) 01/2022 - 03/2013
3	Bipolar Disorder (Manic Depressive Psychosis) 12/2017 - 11/2015
3	Epilepsy (Aura) 08/2011 - 05/2008
3	Hypoxia (Hypoxemia) 02/2011 - 01/2006
3	Spinal Cord Ischemia 07/2006 - 10/2004
3	Astrocytoma (Pilocytic Astrocytoma) 04/2006 - 10/2005
2	Vascular Diseases (Vascular Disease) 05/2023 - 11/2015
2	Neointima 05/2023 - 01/2017
2	Cerebral Hemorrhage 01/2022 - 01/2020
2	Brain Injuries (Brain Injury) 01/2022 - 01/2006
2	Obesity 01/2022 - 05/2010
2	Hyperplasia 01/2019 - 01/2017
2	Brain Diseases (Brain Disorder) 12/2017 - 08/2010
2	Schizophrenia (Dementia Praecox) 12/2017 - 11/2015
2	Cognitive Dysfunction 07/2013 - 06/2013
2	Neuroinflammatory Diseases 07/2008 - 07/2008
2	Brain Neoplasms (Brain Tumor) 01/2006 - 10/2005
1	Acute Lung Injury 03/2024
1	Insulin Resistance 01/2022
1	Non-alcoholic Fatty Liver Disease 01/2022
1	Glucose Intolerance 01/2022
1	Liver Neoplasms (Liver Cancer) 05/2021
1	Neoplasm Metastasis (Metastasis) 05/2021
1	Amnesia (Dissociative Amnesia) 01/2021
1	Corneal Injuries 04/2020
1	Fibrosis (Cirrhosis) 04/2020
1	Corneal Opacity 04/2020
1	Chills 01/2020
1	Muscle Rigidity 01/2020

Drug/Important Bio-Agent (IBA)

11	Proteins (Proteins, Gene)FDA Link 01/2022 - 05/2004
7	Kainic Acid (Kainate)IBA 08/2011 - 01/2003
6	SP-8356IBA 03/2024 - 01/2019
6	CytokinesIBA 03/2024 - 08/2004
6	LipopolysaccharidesIBA 11/2015 - 04/2005
5	Glucose (Dextrose)FDA LinkGeneric 01/2022 - 08/2006
5	AntioxidantsIBA 03/2013 - 01/2004
4	Matrix Metalloproteinases (MMPs)IBA 01/2022 - 07/2008
4	verbenoneIBA 01/2022 - 01/2019
4	Neuroprotective AgentsIBA 01/2020 - 09/2004
4	Dextromethorphan (Racemethorphan)FDA LinkGeneric 12/2006 - 01/2003
3	Metalloproteases (Metalloproteinases)IBA 01/2022 - 05/2017
3	Oxygen (Dioxygen)IBA 01/2022 - 08/2006
3	Tissue Plasminogen Activator (Alteplase)FDA Link 01/2022 - 03/2015
3	CalpainIBA 01/2020 - 07/2006
3	Matrix Metalloproteinase 9 (Gelatinase B)IBA 01/2019 - 10/2005
3	DNA (Deoxyribonucleic Acid)IBA 03/2007 - 01/2004
2	otaplimastatIBA 01/2022 - 01/2020
2	C-Reactive ProteinIBA 01/2022 - 08/2012
2	Therapeutic UsesIBA 01/2022 - 01/2017
2	NF-kappa B (NF-kB)IBA 05/2021 - 01/2007
2	Mitogen-Activated Protein KinasesIBA 05/2021 - 01/2006
2	Immunoglobulins (Immunoglobulin)IBA 04/2020 - 01/2019
2	Cyclophilin AIBA 12/2019 - 01/2017
2	Vitamin D FDA LinkGeneric 01/2019 - 01/2017
2	Biomarkers (Surrogate Marker)IBA 01/2017 - 08/2012
2	Simvastatin (Zocor)FDA LinkGeneric 11/2015 - 04/2006
2	Dihydrotachysterol (AT 10)IBA 03/2015 - 05/2004
2	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA 06/2013 - 08/2006
2	trimethyltinIBA 06/2013 - 08/2011
2	Interleukin-6 (Interleukin 6)IBA 06/2013 - 08/2012
2	3-nitrotyrosineIBA 04/2013 - 04/2005
2	Free RadicalsIBA 03/2013 - 08/2011
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 08/2012 - 04/2006
2	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA 06/2012 - 12/2006
2	GinsenosidesIBA 02/2009 - 01/2009
2	Malondialdehyde (Propanedial)IBA 05/2008 - 05/2004
2	Cysteine (L-Cysteine)FDA Link 09/2006 - 08/2006
2	Transcription Factor AP-1 (Transcription Factor AP 1)IBA 01/2006 - 01/2004
2	Phorbol EstersIBA 01/2006 - 10/2005
2	CalciumIBA 06/2005 - 10/2004
2	CalbindinsIBA 06/2005 - 10/2004
2	dimemorfan (AT 17)IBA 04/2005 - 05/2004
2	DextrorphanIBA 05/2004 - 01/2003
1	c-Mer Tyrosine KinaseIBA 05/2023
1	QuinazolinesIBA 01/2022
1	Tissue Inhibitor of MetalloproteinasesIBA 01/2022
1	Insulin (Novolin)FDA Link 01/2022
1	HemoHIMIBA 01/2021
1	Scopolamine (Hyoscine)FDA Link 01/2021
1	AlkaliesIBA 04/2020
1	Apolipoproteins E (ApoE)IBA 12/2019

Therapy/Procedure

4	Ligation 05/2023 - 01/2006
4	Therapeutics 06/2016 - 08/2010
2	Stents 01/2019 - 01/2017
1	Treatment Delay 01/2022
1	Drug Therapy (Chemotherapy) 05/2021